A practical approach for intracellular protein delivery

Nanovehicles for Intracellular Protein Delivery

Protein therapeutics holds significant promise for improving human health [1,2]. Our organism contains thousands of proteins, which perform essential functions in growth, development and metabolism regulation. Many diseases arise from the alterations in the functions of intracellular proteins [1]. Therefore, the administration of therapeutic proteins has shown great potential in the treatment o...

Silica Nanoparticles for Intracellular Protein Delivery: a Novel Synthesis Approach Using Green Fluorescent Protein

In this study, a novel approach for preparation of green fluorescent protein (GFP)-doped silica nanoparticles with a narrow size distribution is presented. GFP was chosen as a model protein due to its autofluorescence. Protein-doped nanoparticles have a high application potential in the field of intracellular protein delivery. In addition, fluorescently labelled particles can be used for bioima...

Intracellular Protein Delivery for treating Breast Cancer

Development of protein mimics for intracellular delivery.

Designing delivery agents for therapeutics is an ongoing challenge. As treatments and desired cargoes become more complex, the need for improved delivery vehicles becomes critical. Excellent delivery vehicles must ensure the stability of the cargo, maintain the cargo's solubility, and promote efficient delivery and release. In order to address these issues, many research groups have looked to n...

Redox-responsive nanocapsules for intracellular protein delivery.

Direct delivery of proteins to the cytosol of cells holds tremendous potential in biological and medical applications. Engineering vehicles for escorting proteins to the cytosol in a controlled release fashion has thus generated considerable interest. We report here the preparation of redox-responsive single-protein nanocapsules for intracellular protein delivery. Through in situ interfacial po...